Anti-BRCA1 Polyclonal Antibody

品牌：solarbio | 货号：K002286P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K002286P-50ul	solarbio	50ul	960.00元
K002286P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-BRCA1 Polyclonal Antibody
别名	BRCAI;BRCC1;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;PSCP;RNF53
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:50-200.
交叉反应	Human Mouse Rat
蛋白分子量	208kDa
Gene ID	672
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	A synthetic peptide of human BRCA1
性状	液体
Public Immunogen Range	A synthetic peptide of human BRCA1
Subcellular Locations	Chromosome Cytoplasm Cytoplasm Nucleus
Swiss Prot	P38398
克隆类型	Polyclonal Antibody
背景资料	This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.